All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

BACKGROUND: Chemotherapy is the only therapy option for the majority of AML patients, however, there are several limitations for this treatment. Our aim was to find a new chemotherapy strategy that is more effective and less toxic. METHODS: MTT assays and a xenograft mouse model were employed to eva...

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Detalles Bibliográficos
Autores principales: Xu, Zhifei, Shao, JinJin, Li, Lin, Peng, Xueming, Chen, Min, Li, Guanqun, Yan, Hao, Yang, Bo, Luo, Peihua, He, Qiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700651/
https://www.ncbi.nlm.nih.gov/pubmed/26728137
http://dx.doi.org/10.1186/s12885-015-2010-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700651/
https://www.ncbi.nlm.nih.gov/pubmed/26728137
http://dx.doi.org/10.1186/s12885-015-2010-6

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