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The Induction of Heme Oxygenase 1 Decreases Painful Diabetic Neuropathy and Enhances the Antinociceptive Effects of Morphine in Diabetic Mice

Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if treatment with an heme oxygenase 1 (HO-1) inducer, cobalt protoporphyrin IX (CoPP), could modulate the allodynia and hyperalgesia induced by dia...

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Detalles Bibliográficos
Autores principales: Castany, Sílvia, Carcolé, Mireia, Leánez, Sergi, Pol, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701188/
https://www.ncbi.nlm.nih.gov/pubmed/26730587
http://dx.doi.org/10.1371/journal.pone.0146427