Cargando…
High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes
New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral re...
Autores principales: | Reif, David M., Truong, Lisa, Mandrell, David, Marvel, Skylar, Zhang, Guozhu, Tanguay, Robert L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701642/ https://www.ncbi.nlm.nih.gov/pubmed/26126630 http://dx.doi.org/10.1007/s00204-015-1554-1 |
Ejemplares similares
-
Concurrent Evaluation of Mortality and Behavioral Responses: A Fast and Efficient Testing Approach for High-Throughput Chemical Hazard Identification
por: Thunga, Preethi, et al.
Publicado: (2021) -
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment
por: Jaklin, Manuela, et al.
Publicado: (2022) -
A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish
por: Zhang, Guozhu, et al.
Publicado: (2017) -
Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model
por: Wallis, Dylan J., et al.
Publicado: (2022) -
Teratogen-Induced Oxidative Stress Targets Glyceraldehyde-3-Phosphate Dehydrogenase in the Organogenesis Stage Mouse Embryo
por: Schlisser, Ava E., et al.
Publicado: (2010)