Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

Global deficiency of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that regenerates glucocorticoids within cells, promotes angiogenesis, and reduces acute infarct expansion after myocardial infarction (MI), suggesting that 11β-HSD1 activity has an adverse influence on wound healing i...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Christopher I., Jansen, Maurits A., McGregor, Kieran, Mylonas, Katie J., Richardson, Rachel V., Thomson, Adrian, Moran, Carmel M., Seckl, Jonathan R., Walker, Brian R., Chapman, Karen E., Gray, Gillian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701896/
https://www.ncbi.nlm.nih.gov/pubmed/26465199
http://dx.doi.org/10.1210/en.2015-1630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701896/
https://www.ncbi.nlm.nih.gov/pubmed/26465199
http://dx.doi.org/10.1210/en.2015-1630

Ejemplares similares