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Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study

Lack of an effective vaccine results in 9 million new cases of tuberculosis (TB) every year and 1.8 million deaths worldwide. Although many infants are vaccinated at birth with BCG (an attenuated M. bovis), this does not prevent infection or development of TB after childhood. Immune responses necess...

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Detalles Bibliográficos
Autores principales: Ziraldo, Cordelia, Gong, Chang, Kirschner, Denise E., Linderman, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701940/
https://www.ncbi.nlm.nih.gov/pubmed/26779136
http://dx.doi.org/10.3389/fmicb.2015.01477