Low stromal Foxp3(+) regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer

BACKGROUND: Foxp3(+) regulatory T cells (Tregs) play a vital role in preventing autoimmunity, but also suppress antitumour immune responses. Tumour infiltration by Tregs has strong prognostic significance in colorectal cancer, and accumulating evidence suggests that chemotherapy and radiotherapy eff...

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Detalles Bibliográficos
Autores principales: McCoy, M J, Hemmings, C, Miller, T J, Austin, S J, Bulsara, M K, Zeps, N, Nowak, A K, Lake, R A, Platell, C F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702002/
https://www.ncbi.nlm.nih.gov/pubmed/26645238
http://dx.doi.org/10.1038/bjc.2015.427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702002/
https://www.ncbi.nlm.nih.gov/pubmed/26645238
http://dx.doi.org/10.1038/bjc.2015.427

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