Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process

Breakage–fusion–bridge cycles in cancer arise when a broken segment of DNA is duplicated and an end from each copy joined together. This structure then ‘unfolds’ into a new piece of palindromic DNA. This is one mechanism responsible for the localised amplicons observed in cancer genome data. Here we...

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Detalles Bibliográficos
Autores principales: Greenman, C. D., Cooke, S. L., Marshall, J., Stratton, M. R., Campbell, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702116/
https://www.ncbi.nlm.nih.gov/pubmed/25833184
http://dx.doi.org/10.1007/s00285-015-0875-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702116/
https://www.ncbi.nlm.nih.gov/pubmed/25833184
http://dx.doi.org/10.1007/s00285-015-0875-2

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