Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting

ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promo...

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Detalles Bibliográficos
Autores principales: Kralovicova, Jana, Knut, Marcin, Cross, Nicholas C. P., Vorechovsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702124/
https://www.ncbi.nlm.nih.gov/pubmed/26732650
http://dx.doi.org/10.1038/srep18741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702124/
https://www.ncbi.nlm.nih.gov/pubmed/26732650
http://dx.doi.org/10.1038/srep18741

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