Mutations in LRRK2 potentiate age-related impairment of autophagic flux

Autophagy is thought to play a pivotal role in the pathophysiology of Parkinson’s disease, but little is known about how genes linked to PD affect autophagy in the context of aging. We generated lines of C. elegans expressing reporters for the autophagosome and lysosome expressed only in dopaminergi...

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Detalles Bibliográficos
Autores principales: Saha, Shamol, Ash, Peter E. A., Gowda, Vivek, Liu, Liqun, Shirihai, Orian, Wolozin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702340/
https://www.ncbi.nlm.nih.gov/pubmed/26159606
http://dx.doi.org/10.1186/s13024-015-0022-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702340/
https://www.ncbi.nlm.nih.gov/pubmed/26159606
http://dx.doi.org/10.1186/s13024-015-0022-y

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