Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens

Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycoprotein (Env) trimer include conformational and structural instability. Stabilized soluble trimers such as BG505 SOSIP.664 mimic the structure of virion-associated Env but nevertheless sample different conformational st...

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Detalles Bibliográficos
Autores principales: Schiffner, Torben, de Val, Natalia, Russell, Rebecca A., de Taeye, Steven W., de la Peña, Alba Torrents, Ozorowski, Gabriel, Kim, Helen J., Nieusma, Travis, Brod, Florian, Cupo, Albert, Sanders, Rogier W., Moore, John P., Ward, Andrew B., Sattentau, Quentin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702668/
https://www.ncbi.nlm.nih.gov/pubmed/26512083
http://dx.doi.org/10.1128/JVI.01942-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702668/
https://www.ncbi.nlm.nih.gov/pubmed/26512083
http://dx.doi.org/10.1128/JVI.01942-15

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