cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

The replicative DNA polymerase PolIIIα from Escherichia coli is a uniquely fast and processive enzyme. For its activity it relies on the DNA sliding clamp β, the proofreading exonuclease ε and the C-terminal domain of the clamp loader subunit τ. Due to the dynamic nature of the four-protein complex...

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Detalles Bibliográficos
Autores principales: Fernandez-Leiro, Rafael, Conrad, Julian, Scheres, Sjors HW, Lamers, Meindert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703070/
https://www.ncbi.nlm.nih.gov/pubmed/26499492
http://dx.doi.org/10.7554/eLife.11134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703070/
https://www.ncbi.nlm.nih.gov/pubmed/26499492
http://dx.doi.org/10.7554/eLife.11134

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