Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains

The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag). The structure of the JC virus T-ag origin-binding domain (OBD) was recently solved by X-ray crystallography. This structure revealed that the OBD...

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Detalles Bibliográficos
Autores principales: Meinke, Gretchen, Phelan, Paul J., Shin, Jong, Gagnon, David, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703215/
https://www.ncbi.nlm.nih.gov/pubmed/26735515
http://dx.doi.org/10.1371/journal.ppat.1005362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703215/
https://www.ncbi.nlm.nih.gov/pubmed/26735515
http://dx.doi.org/10.1371/journal.ppat.1005362

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