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Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy

[Image: see text] E. coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to deoxynucleotides, a process that requires long-range radical transfer over 35 Å from a tyrosyl radical (Y(122)•) within the β2 subunit to a cysteine residue (C(439)) within the α2 subunit. The radical...

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Detalles Bibliográficos
Autores principales: Seyedsayamdost, Mohammad R., Argirević, Tomislav, Minnihan, Ellen C., Stubbe, JoAnne, Bennati, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703294/
https://www.ncbi.nlm.nih.gov/pubmed/19821570
http://dx.doi.org/10.1021/ja903879w