Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway

BACKGROUND: Spleen enlargement is often detected in patients with liver cirrhosis, but the precise pathogenetic mechanisms behind the phenomenon have not been clearly elucidated. We investigated the pathogenetic mechanisms of splenomegaly in both portal hypertensive patients and rats, and tried to i...

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Detalles Bibliográficos
Autores principales: Chen, Yunyang, Wang, Weijie, Wang, Huakai, Li, Yongjian, Shi, Minmin, Li, Hongwei, Yan, Jiqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703391/
https://www.ncbi.nlm.nih.gov/pubmed/26734934
http://dx.doi.org/10.1371/journal.pone.0141159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703391/
https://www.ncbi.nlm.nih.gov/pubmed/26734934
http://dx.doi.org/10.1371/journal.pone.0141159

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