Cargando…

Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway

BACKGROUND: Spleen enlargement is often detected in patients with liver cirrhosis, but the precise pathogenetic mechanisms behind the phenomenon have not been clearly elucidated. We investigated the pathogenetic mechanisms of splenomegaly in both portal hypertensive patients and rats, and tried to i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yunyang, Wang, Weijie, Wang, Huakai, Li, Yongjian, Shi, Minmin, Li, Hongwei, Yan, Jiqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703391/ https://www.ncbi.nlm.nih.gov/pubmed/26734934 http://dx.doi.org/10.1371/journal.pone.0141159

Ejemplares similares

Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2
por: Wang, Weijie, et al.
Publicado: (2014)

Establishment of a reversible model of prehepatic portal hypertension in rats
por: Zhao, Xin, et al.
Publicado: (2016)

Chronic prehepatic portal hypertension in the rat: is it a type of Metabolic Inflammatory Syndrome?
por: Sánchez-Patán, Fernando, et al.
Publicado: (2008)

Accessory Hepatic Lobe: A Rare Cause of Prehepatic Portal Hypertension in a Child
por: Sağ, Elif, et al.
Publicado: (2018)

Safety and Efficacy of a Novel Shunt Surgery Combined with Foam Sclerotherapy of Varices for Prehepatic Portal Hypertension: A Pilot Study
por: Zhang, Zhe, et al.
Publicado: (2019)

Blockade of the mTOR signaling pathway with rapamycin ameliorates aristolochic acid nephropathy
por: Wu, Minmin, et al.
Publicado: (2020)

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
por: Murray, James T., et al.
Publicado: (2018)

Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor
por: Artoni, Filippo, et al.
Publicado: (2023)

Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells
por: Li, Yongjian, et al.
Publicado: (2017)

Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines
por: Lin, Hugo You-Hsien, et al.
Publicado: (2014)

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
por: Yoon, Mee-Sup
Publicado: (2017)

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
por: Lawrence, Jessica, et al.
Publicado: (2018)

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
por: Querfurth, Henry, et al.
Publicado: (2021)

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
por: Zhang, Xiaoli, et al.
Publicado: (2019)

Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation
por: Abdelrahman, Shaimaa A., et al.
Publicado: (2022)

GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer
por: Scott, Kenneth L., et al.
Publicado: (2009)

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
por: Seto, Belinda
Publicado: (2012)

mTOR kinase structure, mechanism and regulation by the rapamycin-binding domain
por: Yang, Haijuan, et al.
Publicado: (2013)

Brain size is controlled by the mammalian target of rapamycin (mTOR) in mice
por: Kim, Woo-Yang
Publicado: (2015)

The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment
por: Maiese, Kenneth
Publicado: (2020)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
por: Zhao, Wei, et al.
Publicado: (2023)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer
por: Cao, Guo-dong, et al.
Publicado: (2016)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages
por: Yu, Fang-Yi, et al.
Publicado: (2023)

Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)
por: Jimenez, Rosa H., et al.
Publicado: (2010)

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
por: García-Martínez, Juan M., et al.
Publicado: (2009)

The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
por: Hartman, Adam L., et al.
Publicado: (2012)

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses
por: Soliman, Ghada A.
Publicado: (2013)

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
por: Norwitz, Nicholas G., et al.
Publicado: (2020)

Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury
por: Wang, Xiaoping, et al.
Publicado: (2016)

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
por: Feng, Haoran, et al.
Publicado: (2018)

Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex
por: Ji, Shuang, et al.
Publicado: (2017)

Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
por: Park, Jin-A, et al.
Publicado: (2017)

Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
por: Dai, Zhi-Jun, et al.
Publicado: (2013)

Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts
por: Chen, Guochun, et al.
Publicado: (2012)

Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia
por: Yang, Xiao, et al.
Publicado: (2015)

PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway
por: Cheng, Zhi Y, et al.
Publicado: (2008)

Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes
por: Wang, Guo Yan, et al.
Publicado: (2023)

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
por: Chan, S
Publicado: (2004)

New targets for therapy in breast cancer: Mammalian target of rapamycin (mTOR) antagonists
por: Carraway, Hetty, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_1envijbql0ll8tgv3tmqj6ivtd