HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

We previously found that TYK2 tyrosine kinase signaling through its downstream effector phospho-STAT1 (p-STAT1) acts to upregulate BCL2, which in turn mediates aberrant survival of T-cell acute lymphoblastic leukemia (T-ALL) cells. Here we show that pharmacologic inhibition of heat shock protein 90...

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Detalles Bibliográficos
Autores principales: Akahane, Koshi, Sanda, Takaomi, Mansour, Marc R., Radimerski, Thomas, DeAngelo, Daniel J., Weinstock, David M., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703488/
https://www.ncbi.nlm.nih.gov/pubmed/26265185
http://dx.doi.org/10.1038/leu.2015.222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703488/
https://www.ncbi.nlm.nih.gov/pubmed/26265185
http://dx.doi.org/10.1038/leu.2015.222

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