Abasic pivot substitution harnesses target specificity of RNA interference

Gene silencing via RNA interference inadvertently represses hundreds of off-target transcripts. Because small interfering RNAs (siRNAs) can function as microRNAs, avoiding miRNA-like off-target repression is a major challenge. Functional miRNA–target interactions are known to pre-require transitiona...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hye-Sook, Seok, Heeyoung, Lee, Dong Ha, Ham, Juyoung, Lee, Wooje, Youm, Emilia Moonkyung, Yoo, Jin Seon, Lee, Yong-Seung, Jang, Eun-Sook, Chi, Sung Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703836/
https://www.ncbi.nlm.nih.gov/pubmed/26679372
http://dx.doi.org/10.1038/ncomms10154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703836/
https://www.ncbi.nlm.nih.gov/pubmed/26679372
http://dx.doi.org/10.1038/ncomms10154

Ejemplares similares