The propagation of perturbations in rewired bacterial gene networks

What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli. Here we report that concerted patterns of differential expression propagate from reconnected hub genes. The rewirings link promoter regions to dif...

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Detalles Bibliográficos
Autores principales: Baumstark, Rebecca, Hänzelmann, Sonja, Tsuru, Saburo, Schaerli, Yolanda, Francesconi, Mirko, Mancuso, Francesco M., Castelo, Robert, Isalan, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703840/
https://www.ncbi.nlm.nih.gov/pubmed/26670742
http://dx.doi.org/10.1038/ncomms10105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703840/
https://www.ncbi.nlm.nih.gov/pubmed/26670742
http://dx.doi.org/10.1038/ncomms10105

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