The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p

TP53 is mutated in 50% of all cancers, and its function is often compromised in cancers where it is not mutated. Here we demonstrate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 levels through a mechanism that does not involve the negative regulator of p53, MDM2. Instead, Six1...

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Detalles Bibliográficos
Autores principales: Towers, Christina G., Guarnieri, Anna L., Micalizzi, Doug S., Harrell, J. Chuck, Gillen, Austin E., Kim, Jihye, Wang, Chu-An, Oliphant, Michael U.J., Drasin, David J., Guney, Michelle A., Kabos, Peter, Sartorius, Carol A., Tan, Aik-Choon, Perou, Charles M., Espinosa, Joaquin M., Ford, Heide L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703841/
https://www.ncbi.nlm.nih.gov/pubmed/26687066
http://dx.doi.org/10.1038/ncomms10077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703841/
https://www.ncbi.nlm.nih.gov/pubmed/26687066
http://dx.doi.org/10.1038/ncomms10077

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