H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

DNA methylation is essential for mammalian development and physiology. Here we report that the developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH). SAH is a potent feedback i...

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Detalles Bibliográficos
Autores principales: Zhou, Jichun, Yang, Lihua, Zhong, Tianyu, Mueller, Martin, Men, Yi, Zhang, Na, Xie, Juanke, Giang, Karolyn, Chung, Hunter, Sun, Xueguang, Lu, Lingeng, Carmichael, Gordon G, Taylor, Hugh S, Huang, Yingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703905/
https://www.ncbi.nlm.nih.gov/pubmed/26687445
http://dx.doi.org/10.1038/ncomms10221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703905/
https://www.ncbi.nlm.nih.gov/pubmed/26687445
http://dx.doi.org/10.1038/ncomms10221

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