Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1α (HIF-1α) hydroxylation and degradation. Although oxidat...

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Detalles Bibliográficos
Autores principales: Lee, Gibok, Won, Hyung-Sik, Lee, Yoon-Mi, Choi, Jae-Wan, Oh, Taek-In, Jang, Jeong-Hwa, Choi, Dong-Kug, Lim, Beong-Ou, Kim, Young Jun, Park, Jong-Wan, Puigserver, Pere, Lim, Ji-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703963/
https://www.ncbi.nlm.nih.gov/pubmed/26740011
http://dx.doi.org/10.1038/srep18928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703963/
https://www.ncbi.nlm.nih.gov/pubmed/26740011
http://dx.doi.org/10.1038/srep18928

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