Cargando…

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic responses to oxygen deprivation by mediating hypoxia-inducible factor-1α (HIF-1α) hydroxylation and degradation. Although oxidat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Gibok, Won, Hyung-Sik, Lee, Yoon-Mi, Choi, Jae-Wan, Oh, Taek-In, Jang, Jeong-Hwa, Choi, Dong-Kug, Lim, Beong-Ou, Kim, Young Jun, Park, Jong-Wan, Puigserver, Pere, Lim, Ji-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703963/ https://www.ncbi.nlm.nih.gov/pubmed/26740011 http://dx.doi.org/10.1038/srep18928

Ejemplares similares

Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1α mRNA Expression in Malignant Melanoma Cells
por: Park, Eun-Ji, et al.
Publicado: (2017)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
por: Park, Mi Hee, et al.
Publicado: (2014)

LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium
por: Ju, Sujin, et al.
Publicado: (2021)

Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression
por: Oh, Taek-In, et al.
Publicado: (2017)

Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival
por: Andersen, Sigve, et al.
Publicado: (2011)

Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
por: Jian, Cheng-Bang, et al.
Publicado: (2022)

Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
por: Thévenod, Frank, et al.
Publicado: (2022)

Black Rice (Oryza sativa L.) Fermented with Lactobacillus casei Attenuates Osteoclastogenesis and Ovariectomy-Induced Osteoporosis
por: Lee, Young Min, et al.
Publicado: (2019)

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies
por: Fielding, James W., et al.
Publicado: (2018)

Adipose-Derived Mesenchymal Stem Cells Reprogram M1 Macrophage Metabolism via PHD2/HIF-1α Pathway in Colitis Mice
por: Yuan, Yin, et al.
Publicado: (2022)

Roxadustat, a HIF-PHD inhibitor with exploitable potential on diabetes-related complications
por: Fang, Tingting, et al.
Publicado: (2023)

The Effects of Aronia melanocarpa ‘Viking’ Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling
por: Ghosh, Mithun, et al.
Publicado: (2018)

Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends
por: Mijan, Mohammad Al, et al.
Publicado: (2018)

Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1
por: Bayazid, Al Borhan, et al.
Publicado: (2022)

Study on the Expressions of PHD and HIF in Placentas from Normal Pregnant Women and Patients with Preeclampsia
por: Liu, Wei, et al.
Publicado: (2014)

Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
por: Martin-Puig, Silvia, et al.
Publicado: (2015)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Natural Products as a Source of Anti-Inflammatory Agents Associated with Inflammatory Bowel Disease
por: Debnath, Trishna, et al.
Publicado: (2013)

Acetylcholinesterase Inhibition and in Vitro and in Vivo Antioxidant Activities of Ganoderma lucidum Grown on Germinated Brown Rice
por: Hasnat, Md. Abul, et al.
Publicado: (2013)

Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells
por: Seo, Jieun, et al.
Publicado: (2020)

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
por: Hodson, Emma J., et al.
Publicado: (2015)

Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
por: Dey, Anindya, et al.
Publicado: (2020)

Characterization of the Key Determinants of Phd Antitoxin Mediated Doc Toxin Inactivation in Salmonella
por: de Castro, Guilherme V., et al.
Publicado: (2022)

Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
por: Hasnat, Md. Abul, et al.
Publicado: (2015)

Fermented Aronia melanocarpa Inhibits Melanogenesis through Dual Mechanisms of the PI3K/AKT/GSK-3β and PKA/CREB Pathways
por: Kim, Da Hee, et al.
Publicado: (2023)

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways
por: Lim, Seon Ah, et al.
Publicado: (2021)

Conditional Inactivation of HIF-1 Using Intrabodies
por: Groot, Arjan J., et al.
Publicado: (2008)

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
por: Kim, Min, et al.
Publicado: (2014)

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
por: Madsen, Chris D, et al.
Publicado: (2015)

Hif1a and Hif2a can be safely inactivated in cone photoreceptors
por: Samardzija, Marijana, et al.
Publicado: (2019)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

Inhibition of HIF1α and PDK Induces Cell Death of Glioblastoma Multiforme
por: Han, Jiwon Esther, et al.
Publicado: (2017)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
por: Astuti, Dewi, et al.
Publicado: (2011)

HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages
por: Nagashima, Ryuichi, et al.
Publicado: (2023)

Lanthanide-Doped Upconversion Nanocarriers for Drug and Gene Delivery
por: Lee, Gibok, et al.
Publicado: (2018)

Cell-Surface Loss of Constitutive Activating and Inactivating Mutants of Eel Luteinizing Hormone Receptors
por: Byambaragchaa, Munkhzaya, et al.
Publicado: (2021)

Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics
por: Motta, Stefano, et al.
Publicado: (2018)

Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
por: Lee, Yoon-Mi, et al.
Publicado: (2019)

Improved Bearings-Only Multi-Target Tracking with GM-PHD Filtering
por: Zhang, Qian, et al.
Publicado: (2016)

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma
por: Tanaka, Takayuki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4e38dl8qnobf5tsggm74gu7k5j