Two-Step Delivery: Exploiting the Partition Coefficient Concept to Increase Intratumoral Paclitaxel Concentrations In vivo Using Responsive Nanoparticles

Drug dose, high local target tissue concentration, and prolonged duration of exposure are essential criteria in achieving optimal drug performance. However, systemically delivered drugs often fail to effectively address these factors with only fractions of the injected dose reaching the target tissu...

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Detalles Bibliográficos
Autores principales: Colby, Aaron H., Liu, Rong, Schulz, Morgan D., Padera, Robert F., Colson, Yolonda L., Grinstaff, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703988/
https://www.ncbi.nlm.nih.gov/pubmed/26740245
http://dx.doi.org/10.1038/srep18720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703988/
https://www.ncbi.nlm.nih.gov/pubmed/26740245
http://dx.doi.org/10.1038/srep18720

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