Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities

APOBEC1 (A1) proteins from lagomorphs and rodents have deaminase-dependent restriction activity against HIV-1, whereas human A1 exerts a negligible effect. To investigate these differences in the restriction of HIV-1 by A1 proteins, a series of chimeric proteins combining rabbit and human A1s was co...

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Detalles Bibliográficos
Autores principales: Ikeda, Terumasa, Ong, Eugene Boon Beng, Watanabe, Nobumoto, Sakaguchi, Nobuo, Maeda, Kazuhiko, Koito, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704027/
https://www.ncbi.nlm.nih.gov/pubmed/26738439
http://dx.doi.org/10.1038/srep19035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704027/
https://www.ncbi.nlm.nih.gov/pubmed/26738439
http://dx.doi.org/10.1038/srep19035

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