Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization

Bacterial type I signal peptidases (SPases) are membrane-anchored serine proteases that process the signal peptides of proteins exported via the Sec and Tat secretion systems. Despite their crucial importance for bacterial virulence and their attractiveness as drug targets, only one such enzyme, Lep...

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Detalles Bibliográficos
Autores principales: Ting, Yi Tian, Harris, Paul W. R., Batot, Gaelle, Brimble, Margaret A., Baker, Edward N., Young, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2016
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704075/
https://www.ncbi.nlm.nih.gov/pubmed/26870377
http://dx.doi.org/10.1107/S2052252515019971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704075/
https://www.ncbi.nlm.nih.gov/pubmed/26870377
http://dx.doi.org/10.1107/S2052252515019971

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