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Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization
Bacterial type I signal peptidases (SPases) are membrane-anchored serine proteases that process the signal peptides of proteins exported via the Sec and Tat secretion systems. Despite their crucial importance for bacterial virulence and their attractiveness as drug targets, only one such enzyme, Lep...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704075/ https://www.ncbi.nlm.nih.gov/pubmed/26870377 http://dx.doi.org/10.1107/S2052252515019971 |