Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency exhibits considerable allelic heterogeneity which manifests with variable biochemical and clinical penetrance. It has long been thought that G6PD deficiency confers partial protection against severe malaria, however prior genetic associ...

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Detalles Bibliográficos
Autores principales: Shah, Shivang S., Rockett, Kirk A., Jallow, Muminatou, Sisay-Joof, Fatou, Bojang, Kalifa A., Pinder, Margaret, Jeffreys, Anna, Craik, Rachel, Hubbart, Christina, Wellems, Thomas E., Kwiatkowski, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704392/
https://www.ncbi.nlm.nih.gov/pubmed/26738565
http://dx.doi.org/10.1186/s12936-015-1045-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704392/
https://www.ncbi.nlm.nih.gov/pubmed/26738565
http://dx.doi.org/10.1186/s12936-015-1045-0

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