Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics

Enabling the implementation of top down proteomic techniques within clinical workflows requires a dramatic increase in sensitivity. It has been previously demonstrated that electrospray ionization (ESI) becomes more efficient with decreasing volumetric flow rates at the emitter. Therefore, narrow in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Kyunggon, Compton, Philip D., Toby, Timothy K., Thomas, Paul M., Wilkins, John T., Mutharasan, R. Kannan, Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704458/
https://www.ncbi.nlm.nih.gov/pubmed/26753126
http://dx.doi.org/10.1016/j.euprot.2015.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704458/
https://www.ncbi.nlm.nih.gov/pubmed/26753126
http://dx.doi.org/10.1016/j.euprot.2015.05.005

Ejemplares similares