Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher‐order organization remains elusive....

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Detalles Bibliográficos
Autores principales: Fraser, James, Ferrai, Carmelo, Chiariello, Andrea M, Schueler, Markus, Rito, Tiago, Laudanno, Giovanni, Barbieri, Mariano, Moore, Benjamin L, Kraemer, Dorothee CA, Aitken, Stuart, Xie, Sheila Q, Morris, Kelly J, Itoh, Masayoshi, Kawaji, Hideya, Jaeger, Ines, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair RR, Semple, Colin A, Dostie, Josée, Pombo, Ana, Nicodemi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704492/
https://www.ncbi.nlm.nih.gov/pubmed/26700852
http://dx.doi.org/10.15252/msb.20156492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704492/
https://www.ncbi.nlm.nih.gov/pubmed/26700852
http://dx.doi.org/10.15252/msb.20156492

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