CYP2D6 copy number distribution in the US population

The cytochrome P450 2D6 (CYP2D6) gene is perhaps the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants that are inheritable and stable. In a set of over 30 000 deidentified clinical samples we found that 12.6% of all patients te...

Descripción completa

Detalles Bibliográficos
Autores principales: Beoris, Michelle, Amos Wilson, Jean, Garces, Jorge A., Lukowiak, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704658/
https://www.ncbi.nlm.nih.gov/pubmed/26551314
http://dx.doi.org/10.1097/FPC.0000000000000188
_version_ 1782408897687977984
author Beoris, Michelle
Amos Wilson, Jean
Garces, Jorge A.
Lukowiak, Andrew A.
author_facet Beoris, Michelle
Amos Wilson, Jean
Garces, Jorge A.
Lukowiak, Andrew A.
author_sort Beoris, Michelle
collection PubMed
description The cytochrome P450 2D6 (CYP2D6) gene is perhaps the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants that are inheritable and stable. In a set of over 30 000 deidentified clinical samples we found that 12.6% of all patients tested had zero, one, or three or more copies of the CYP2D6 gene. On the basis of the combined frequency and impact of these variants, we believe that CYP2D6 copy number variation may account for the single most impactful genetic anomaly as it relates to pharmacogenetic directed therapies.
format Online
Article
Text
id pubmed-4704658
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-47046582016-01-19 CYP2D6 copy number distribution in the US population Beoris, Michelle Amos Wilson, Jean Garces, Jorge A. Lukowiak, Andrew A. Pharmacogenet Genomics Short Communications The cytochrome P450 2D6 (CYP2D6) gene is perhaps the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants that are inheritable and stable. In a set of over 30 000 deidentified clinical samples we found that 12.6% of all patients tested had zero, one, or three or more copies of the CYP2D6 gene. On the basis of the combined frequency and impact of these variants, we believe that CYP2D6 copy number variation may account for the single most impactful genetic anomaly as it relates to pharmacogenetic directed therapies. Lippincott Williams & Wilkins 2016-02 2016-01-06 /pmc/articles/PMC4704658/ /pubmed/26551314 http://dx.doi.org/10.1097/FPC.0000000000000188 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Short Communications
Beoris, Michelle
Amos Wilson, Jean
Garces, Jorge A.
Lukowiak, Andrew A.
CYP2D6 copy number distribution in the US population
title CYP2D6 copy number distribution in the US population
title_full CYP2D6 copy number distribution in the US population
title_fullStr CYP2D6 copy number distribution in the US population
title_full_unstemmed CYP2D6 copy number distribution in the US population
title_short CYP2D6 copy number distribution in the US population
title_sort cyp2d6 copy number distribution in the us population
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704658/
https://www.ncbi.nlm.nih.gov/pubmed/26551314
http://dx.doi.org/10.1097/FPC.0000000000000188
work_keys_str_mv AT beorismichelle cyp2d6copynumberdistributionintheuspopulation
AT amoswilsonjean cyp2d6copynumberdistributionintheuspopulation
AT garcesjorgea cyp2d6copynumberdistributionintheuspopulation
AT lukowiakandrewa cyp2d6copynumberdistributionintheuspopulation

Ejemplares similares