Downregulating Galectin-3 Inhibits Proinflammatory Cytokine Production by Human Monocyte-Derived Dendritic Cells

Galectin-3 (Gal-3), a β-galactoside-binding lectin, serves as a pattern-recognition receptor (PRR) of dendritic cells (DCs) in regulating proinflammatory cytokine production. Galectin-3 (Gal-3) siRNA downregulates expression of IL-6, IL-1β and IL-23 p19, while upregulates IL-10 and IL-12 p35 in TLR/...

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Detalles Bibliográficos
Autores principales: Chen, Swey-Shen, Sun, Liang-Wu, Brickner, Howard, Sun, Pei-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704704/
https://www.ncbi.nlm.nih.gov/pubmed/25684095
http://dx.doi.org/10.1016/j.cellimm.2015.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704704/
https://www.ncbi.nlm.nih.gov/pubmed/25684095
http://dx.doi.org/10.1016/j.cellimm.2015.01.017

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