Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation

We accumulated mutations for 1952 generations in 79 initially identical, haploid lines of the fission yeast Schizosaccharomyces pombe, and then performed whole-genome sequencing to determine the mutation rates and spectrum. We captured 696 spontaneous mutations across the 79 mutation accumulation (M...

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Detalles Bibliográficos
Autores principales: Behringer, Megan G., Hall, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704713/
https://www.ncbi.nlm.nih.gov/pubmed/26564949
http://dx.doi.org/10.1534/g3.115.022129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704713/
https://www.ncbi.nlm.nih.gov/pubmed/26564949
http://dx.doi.org/10.1534/g3.115.022129

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