Cargando…

Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites

The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niu, Jing, Arentshorst, Mark, Nair, P. Deepa S., Dai, Ziyu, Baker, Scott E., Frisvad, Jens C., Nielsen, Kristian F., Punt, Peter J., Ram, Arthur F.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2015
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704718/ https://www.ncbi.nlm.nih.gov/pubmed/26566947 http://dx.doi.org/10.1534/g3.115.024067

Ejemplares similares

Itaconic acid production is regulated by LaeA in Aspergillus pseudoterreus
por: Pomraning, Kyle R., et al.
Publicado: (2022)

Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
por: Perrin, Robyn M, et al.
Publicado: (2007)

A Cellular Fusion Cascade Regulated by LaeA Is Required for Sclerotial Development in Aspergillus flavus
por: Zhao, Xixi, et al.
Publicado: (2017)

Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans
por: Moon, Heungyun, et al.
Publicado: (2023)

LaeA-Regulated Fungal Traits Mediate Bacterial Community Assembly
por: Tannous, Joanna, et al.
Publicado: (2023)

Heteroexpression of Aspergillus nidulans laeA in Marine-Derived Fungi Triggers Upregulation of Secondary Metabolite Biosynthetic Genes
por: Khan, Ishrat, et al.
Publicado: (2020)

A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi
por: Luo, Qin, et al.
Publicado: (2022)

Functional roles of LaeA, polyketide synthase, and glucose oxidase in the regulation of ochratoxin A biosynthesis and virulence in Aspergillus carbonarius
por: Maor, Uriel, et al.
Publicado: (2020)

An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus
por: Lind, Abigail L., et al.
Publicado: (2018)

The Kinetochore Protein Spc105, a Novel Interaction Partner of LaeA, Regulates Development and Secondary Metabolism in Aspergillus flavus
por: Zhi, Qing-Qing, et al.
Publicado: (2019)

Requirement of LaeA, VeA, and VelB on Asexual Development, Ochratoxin A Biosynthesis, and Fungal Virulence in Aspergillus ochraceus
por: Wang, Gang, et al.
Publicado: (2019)

The Different Roles of Penicillium oxalicum LaeA in the Production of Extracellular Cellulase and β-xylosidase
por: Li, Yanan, et al.
Publicado: (2016)

LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali
por: Feng, Yaqiong, et al.
Publicado: (2020)

The putative methyltransferase LaeA regulates mycelium growth and cellulase production in Myceliophthora thermophila
por: Zhao, Zhen, et al.
Publicado: (2023)

Interrogation of the cell wall integrity pathway in Aspergillus niger identifies a putative negative regulator of transcription involved in chitin deposition
por: van Leeuwe, Tim M., et al.
Publicado: (2020)

Comparative transcriptomics analysis of compatible wild type and incompatible ΔlaeA mutant strains of Epichloë festucae in association with perennial ryegrass
por: Rahnama, M., et al.
Publicado: (2019)

A new vector for efficient gene targeting to the pyrG locus in Aspergillus niger
por: Arentshorst, Mark, et al.
Publicado: (2015)

LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity
por: Sarikaya Bayram, Özlem, et al.
Publicado: (2010)

VelA and LaeA are Key Regulators of Epichloë festucae Transcriptomic Response during Symbiosis with Perennial Ryegrass
por: Rahnama, Mostafa, et al.
Publicado: (2019)

Functional Roles of LaeA-like Genes in Fungal Growth, Cellulase Activity, and Secondary Metabolism in Pleurotus ostreatus
por: Zhang, Guang, et al.
Publicado: (2022)

The transcriptomic fingerprint of glucoamylase over-expression in Aspergillus niger
por: Kwon, Min Jin, et al.
Publicado: (2012)

Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger
por: Sgro, Michael, et al.
Publicado: (2023)

Fumonisin and Ochratoxin Production in Industrial Aspergillus niger Strains
por: Frisvad, Jens C., et al.
Publicado: (2011)

A set of isogenic auxotrophic strains for constructing multiple gene deletion mutants and parasexual crossings in Aspergillus niger
por: Niu, Jing, et al.
Publicado: (2016)

Mutations in AraR leading to constitutive of arabinolytic genes in Aspergillus niger under derepressing conditions
por: Reijngoud, Jos, et al.
Publicado: (2019)

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
por: Yu, Jing, et al.
Publicado: (2019)

Inhibition of oxidative phosphorylation for enhancing citric acid production by Aspergillus niger
por: Wang, Lu, et al.
Publicado: (2015)

A seven-membered cell wall related transglycosylase gene family in Aspergillus niger is relevant for cell wall integrity in cell wall mutants with reduced α-glucan or galactomannan
por: van Leeuwe, Tim M., et al.
Publicado: (2020)

The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production
por: Aerts, David, et al.
Publicado: (2017)

Apple Intrinsic Factors Modulating the Global Regulator, LaeA, the Patulin Gene Cluster and Patulin Accumulation During Fruit Colonization by Penicillium expansum
por: Kumar, Dilip, et al.
Publicado: (2018)

Improving cellulase production by Aspergillus niger using adaptive evolution
por: Patyshakuliyeva, Aleksandrina, et al.
Publicado: (2016)

Citric Acid Production by Aspergillus niger Cultivated on Parkia biglobosa Fruit Pulp
por: Auta, Helen Shnada, et al.
Publicado: (2014)

Heterogeneity in liquid shaken cultures of Aspergillus niger inoculated with melanised conidia or conidia of pigmentation mutants
por: van Veluw, G.J., et al.
Publicado: (2013)

Loss of function of the carbon catabolite repressor CreA leads to low but inducer‐independent expression from the feruloyl esterase B promoter in Aspergillus niger
por: Reijngoud, Jos, et al.
Publicado: (2021)

Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era
por: Tong, Zhenyu, et al.
Publicado: (2019)

Bioreactor as the root cause of the “manganese effect” during Aspergillus niger citric acid fermentations
por: Fekete, Erzsébet, et al.
Publicado: (2022)

Effect of temperature and water activity on the production of fumonisins by Aspergillus niger and different Fusarium species
por: Mogensen, Jesper M, et al.
Publicado: (2009)

Application of methanol and sweet potato vine hydrolysate as enhancers of citric acid production by Aspergillus niger
por: Yu, Daobing, et al.
Publicado: (2017)

Optimization of citric acid production by Aspergillus niger using two downgraded Algerian date varieties
por: Chergui, Dallal, et al.
Publicado: (2021)

Genome-wide transcription landscape of citric acid producing Aspergillus niger in response to glucose gradient
por: Zheng, Xiaomei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6k9qbtc095mjs4halk2rp3jd3j