Effect of Methamphetamine on Spectral Binding, Ligand Docking and Metabolism of Anti-HIV Drugs with CYP3A4

Cytochrome P450 3A4 (CYP3A4) is the major drug metabolic enzyme, and is involved in the metabolism of antiretroviral drugs, especially protease inhibitors (PIs). This study was undertaken to examine the effect of methamphetamine on the binding and metabolism of PIs with CYP3A4. We showed that metham...

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Detalles Bibliográficos
Autores principales: Nookala, Anantha R., Li, Junhao, Ande, Anusha, Wang, Lei, Vaidya, Naveen K., Li, Weihua, Kumar, Santosh, Kumar, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704828/
https://www.ncbi.nlm.nih.gov/pubmed/26741368
http://dx.doi.org/10.1371/journal.pone.0146529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704828/
https://www.ncbi.nlm.nih.gov/pubmed/26741368
http://dx.doi.org/10.1371/journal.pone.0146529

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