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Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits

It has been suggested that pharmacogenomic phenotypes are influenced by genetic variants with larger effect sizes than other phenotypes, such as complex disease risk. This is presumed to reflect the fact that relevant environmental factors (drug exposure) are appropriately measured and taken into ac...

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Detalles Bibliográficos
Autores principales: Maranville, Joseph C., Cox, Nancy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704992/
https://www.ncbi.nlm.nih.gov/pubmed/26149738
http://dx.doi.org/10.1038/tpj.2015.47