Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines

PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP) activity with trabectedin and PARP inhibitors, respectively,...

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Detalles Bibliográficos
Autores principales: Ávila-Arroyo, Sonia, Nuñez, Gema Santamaría, García-Fernández, Luis Francisco, Galmarini, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705084/
https://www.ncbi.nlm.nih.gov/pubmed/26770239
http://dx.doi.org/10.4048/jbc.2015.18.4.329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705084/
https://www.ncbi.nlm.nih.gov/pubmed/26770239
http://dx.doi.org/10.4048/jbc.2015.18.4.329

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