Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials

In this study, we present identification and physicochemical characterization of new cathinone derivatives, 4-fluoro-PV9 and already known α-PHP in seized materials. Although the disclosure of α-PHP from an illegal product had been reported and characterized to some extent, the data on α-PHP are als...

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Autores principales: Majchrzak, Milena, Rojkiewicz, Marcin, Celiński, Rafał, Kuś, Piotr, Sajewicz, Mieczysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705138/
https://www.ncbi.nlm.nih.gov/pubmed/26793278
http://dx.doi.org/10.1007/s11419-015-0295-4
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author Majchrzak, Milena
Rojkiewicz, Marcin
Celiński, Rafał
Kuś, Piotr
Sajewicz, Mieczysław
author_facet Majchrzak, Milena
Rojkiewicz, Marcin
Celiński, Rafał
Kuś, Piotr
Sajewicz, Mieczysław
author_sort Majchrzak, Milena
collection PubMed
description In this study, we present identification and physicochemical characterization of new cathinone derivatives, 4-fluoro-PV9 and already known α-PHP in seized materials. Although the disclosure of α-PHP from an illegal product had been reported and characterized to some extent, the data on α-PHP are also presented together with those of 4-fluoro-PV9. The data of characterization for the two compounds were obtained by high-performance liquid chromatography (HPLC)–mass spectrometry and HPLC–diode array detection, electrospray ionization/ion trap mass spectrometry in MS(2) and MS(3) modes, gas chromatography–mass spectrometry, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, and nuclear magnetic resonance spectroscopy. To our knowledge, this is the first report for identification and detailed characterization of 4-fluoro-PV9 circulated on the illegal drug market.
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spelling pubmed-47051382016-01-18 Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials Majchrzak, Milena Rojkiewicz, Marcin Celiński, Rafał Kuś, Piotr Sajewicz, Mieczysław Forensic Toxicol Original Article In this study, we present identification and physicochemical characterization of new cathinone derivatives, 4-fluoro-PV9 and already known α-PHP in seized materials. Although the disclosure of α-PHP from an illegal product had been reported and characterized to some extent, the data on α-PHP are also presented together with those of 4-fluoro-PV9. The data of characterization for the two compounds were obtained by high-performance liquid chromatography (HPLC)–mass spectrometry and HPLC–diode array detection, electrospray ionization/ion trap mass spectrometry in MS(2) and MS(3) modes, gas chromatography–mass spectrometry, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, and nuclear magnetic resonance spectroscopy. To our knowledge, this is the first report for identification and detailed characterization of 4-fluoro-PV9 circulated on the illegal drug market. Springer Japan 2015-10-13 2016 /pmc/articles/PMC4705138/ /pubmed/26793278 http://dx.doi.org/10.1007/s11419-015-0295-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Majchrzak, Milena
Rojkiewicz, Marcin
Celiński, Rafał
Kuś, Piotr
Sajewicz, Mieczysław
Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title_full Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title_fullStr Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title_full_unstemmed Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title_short Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials
title_sort identification and characterization of new designer drug 4-fluoro-pv9 and α-php in the seized materials
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705138/
https://www.ncbi.nlm.nih.gov/pubmed/26793278
http://dx.doi.org/10.1007/s11419-015-0295-4
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