Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice

Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS targets in mouse models prior to the development of specific ligands. Here for the first time, we have implemented this strategy to address the potential therapeutic value of a glutamate-based pharmacot...

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Detalles Bibliográficos
Autores principales: Mingote, Susana, Masson, Justine, Gellman, Celia, Thomsen, Gretchen M., Lin, Chyuan-Sheng, Merker, Robert J., Gaisler-Salomon, Inna, Wang, Yvonne, Ernst, Rachel, Hen, René, Rayport, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705219/
https://www.ncbi.nlm.nih.gov/pubmed/26778975
http://dx.doi.org/10.3389/fnsys.2015.00165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705219/
https://www.ncbi.nlm.nih.gov/pubmed/26778975
http://dx.doi.org/10.3389/fnsys.2015.00165

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