Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia

Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced AML, and PU.1 downregulation and/or dysfunction ha...

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Detalles Bibliográficos
Autores principales: Sive, J I, Basilico, S, Hannah, R, Kinston, S J, Calero-Nieto, F J, Göttgens, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705427/
https://www.ncbi.nlm.nih.gov/pubmed/26126967
http://dx.doi.org/10.1038/leu.2015.172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705427/
https://www.ncbi.nlm.nih.gov/pubmed/26126967
http://dx.doi.org/10.1038/leu.2015.172

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