DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia

Close to half of de novo acute myeloid leukemia (AML) cases do not exhibit any cytogenetic aberrations. In this regard, distortion of the DNA methylation setting and the presence of mutations in epigenetic modifier genes can also be molecular drivers of the disease. In recent years, somatic missense...

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Detalles Bibliográficos
Autores principales: Ferreira, H J, Heyn, H, Vizoso, M, Moutinho, C, Vidal, E, Gomez, A, Martínez-Cardús, A, Simó-Riudalbas, L, Moran, S, Jost, E, Esteller, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705435/
https://www.ncbi.nlm.nih.gov/pubmed/26434589
http://dx.doi.org/10.1038/onc.2015.359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705435/
https://www.ncbi.nlm.nih.gov/pubmed/26434589
http://dx.doi.org/10.1038/onc.2015.359

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