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Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration

We have previously reported that a synthetic mechano-growth factor (MGF) C-terminal E-domain with 25 amino acids (MGF-C25E) promotes rat tenocyte migration through the FAK-ERK1/2 signaling pathway. However, the role of the nucleus in MGF-C25E-promoted tenocyte migration and the molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Zhang, Bingyu, Luo, Qing, Chen, Zhen, Shi, Yisong, Ju, Yang, Yang, Li, Song, Guanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705462/
https://www.ncbi.nlm.nih.gov/pubmed/26742689
http://dx.doi.org/10.1038/srep18809