CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Heat-shock protein 90 (Hsp90) is highly expressed in many tumor cells and is associated with the maintenance of malignant phenotypes. Targeting Hsp90 has had therapeutic success in both solid and hematological malignancies, which has inspired more studies to identify new Hsp90 inhibitors with improv...

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Detalles Bibliográficos
Autores principales: Xu, Xiao-Li, Bao, Qi-chao, Jia, Jian-Min, Liu, Fang, Guo, Xiao-Ke, Zhang, Ming-ye, Wei, Jin-lian, Lu, Meng-chen, Xu, Li-li, Zhang, Xiao-Jin, You, Qi-Dong, Sun, Hao-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705544/
https://www.ncbi.nlm.nih.gov/pubmed/26743233
http://dx.doi.org/10.1038/srep19004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705544/
https://www.ncbi.nlm.nih.gov/pubmed/26743233
http://dx.doi.org/10.1038/srep19004

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