Automated physics-based design of synthetic riboswitches from diverse RNA aptamers

Riboswitches are shape-changing regulatory RNAs that bind chemicals and regulate gene expression, directly coupling sensing to cellular actuation. However, it remains unclear how their sequence controls the physics of riboswitch switching and activation, particularly when changing the ligand-binding...

Descripción completa

Detalles Bibliográficos
Autores principales: Espah Borujeni, Amin, Mishler, Dennis M., Wang, Jingzhi, Huso, Walker, Salis, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705656/
https://www.ncbi.nlm.nih.gov/pubmed/26621913
http://dx.doi.org/10.1093/nar/gkv1289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705656/
https://www.ncbi.nlm.nih.gov/pubmed/26621913
http://dx.doi.org/10.1093/nar/gkv1289

Ejemplares similares