Functional dichotomy in the 16S rRNA (m(1)A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization

Methylation of the bacterial small ribosomal subunit (16S) rRNA on the N1 position of A1408 confers exceptionally high-level resistance to a broad spectrum of aminoglycoside antibiotics. Here, we present a detailed structural and functional analysis of the Catenulisporales acidiphilia 16S rRNA (m(1)...

Descripción completa

Detalles Bibliográficos
Autores principales: Witek, Marta A., Conn, Graeme L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705659/
https://www.ncbi.nlm.nih.gov/pubmed/26609134
http://dx.doi.org/10.1093/nar/gkv1306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705659/
https://www.ncbi.nlm.nih.gov/pubmed/26609134
http://dx.doi.org/10.1093/nar/gkv1306

Ejemplares similares