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Functional dichotomy in the 16S rRNA (m(1)A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization
Methylation of the bacterial small ribosomal subunit (16S) rRNA on the N1 position of A1408 confers exceptionally high-level resistance to a broad spectrum of aminoglycoside antibiotics. Here, we present a detailed structural and functional analysis of the Catenulisporales acidiphilia 16S rRNA (m(1)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705659/ https://www.ncbi.nlm.nih.gov/pubmed/26609134 http://dx.doi.org/10.1093/nar/gkv1306 |