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A general strategy to inhibiting viral −1 frameshifting based on upstream attenuation duplex formation
Viral −1 programmed ribosomal frameshifting (PRF) as a potential antiviral target has attracted interest because many human viral pathogens, including human immunodeficiency virus (HIV) and coronaviruses, rely on −1 PRF for optimal propagation. Efficient eukaryotic −1 PRF requires an optimally place...
Autores principales: | Hu, Hao-Teng, Cho, Che-Pei, Lin, Ya-Hui, Chang, Kung-Yao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705660/ https://www.ncbi.nlm.nih.gov/pubmed/26612863 http://dx.doi.org/10.1093/nar/gkv1307 |
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