Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners

YabA negatively regulates initiation of DNA replication in low-GC Gram-positive bacteria. The protein exerts its control through interactions with the initiator protein DnaA and the sliding clamp DnaN. Here, we combined X-ray crystallography, X-ray scattering (SAXS), modeling and biophysical approac...

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Detalles Bibliográficos
Autores principales: Felicori, Liza, Jameson, Katie H., Roblin, Pierre, Fogg, Mark J., Garcia-Garcia, Transito, Ventroux, Magali, Cherrier, Mickaël V., Bazin, Alexandre, Noirot, Philippe, Wilkinson, Anthony J., Molina, Franck, Terradot, Laurent, Noirot-Gros, Marie-Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705661/
https://www.ncbi.nlm.nih.gov/pubmed/26615189
http://dx.doi.org/10.1093/nar/gkv1318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705661/
https://www.ncbi.nlm.nih.gov/pubmed/26615189
http://dx.doi.org/10.1093/nar/gkv1318

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