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Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners
YabA negatively regulates initiation of DNA replication in low-GC Gram-positive bacteria. The protein exerts its control through interactions with the initiator protein DnaA and the sliding clamp DnaN. Here, we combined X-ray crystallography, X-ray scattering (SAXS), modeling and biophysical approac...
Autores principales: | Felicori, Liza, Jameson, Katie H., Roblin, Pierre, Fogg, Mark J., Garcia-Garcia, Transito, Ventroux, Magali, Cherrier, Mickaël V., Bazin, Alexandre, Noirot, Philippe, Wilkinson, Anthony J., Molina, Franck, Terradot, Laurent, Noirot-Gros, Marie-Françoise |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705661/ https://www.ncbi.nlm.nih.gov/pubmed/26615189 http://dx.doi.org/10.1093/nar/gkv1318 |
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