L1 retrotransposition requires rapid ORF1p oligomerization, a novel coiled coil-dependent property conserved despite extensive remodeling

Detailed mechanistic understanding of L1 retrotransposition is sparse, particularly with respect to ORF1p, a coiled coil-mediated homotrimeric nucleic acid chaperone that can form tightly packed oligomers on nucleic acids. Although the coiled coil motif is highly conserved, it is uniquely susceptibl...

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Detalles Bibliográficos
Autores principales: Naufer, M. Nabuan, Callahan, Kathryn E., Cook, Pamela R., Perez-Gonzalez, Cesar E., Williams, Mark C., Furano, Anthony V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705668/
https://www.ncbi.nlm.nih.gov/pubmed/26673717
http://dx.doi.org/10.1093/nar/gkv1342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705668/
https://www.ncbi.nlm.nih.gov/pubmed/26673717
http://dx.doi.org/10.1093/nar/gkv1342

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