A DNAzyme requiring two different metal ions at two distinct sites

Most previously reported RNA-cleaving DNAzymes require only a single divalent metal ion for catalysis. We recently reported a general trivalent lanthanide-dependent DNAzyme named Ce13d. This work shows that Ce13d requires both Na(+) and a trivalent lanthanide (e.g. Ce(3+)), simultaneously. This disc...

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Detalles Bibliográficos
Autores principales: Zhou, Wenhu, Zhang, Yupei, Huang, Po-Jung Jimmy, Ding, Jinsong, Liu, Juewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705669/
https://www.ncbi.nlm.nih.gov/pubmed/26657636
http://dx.doi.org/10.1093/nar/gkv1346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705669/
https://www.ncbi.nlm.nih.gov/pubmed/26657636
http://dx.doi.org/10.1093/nar/gkv1346

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